- "Sounds like you have a dick in your mouth."
- ―Blind Al
While at a laundromat one day, Al ran into Wade Wilson, who was in the middle of removing bloodstains from his clothes. Eventually, Wade would move into Al's house while hunting down Ajax, the man responsible for disfiguring him. One day, after escaping Colossus and Negasonic Teenage Warhead, Wade returned to Al's home to rest while the old woman assembled a cabinet that ultimately fell apart, causing her to complain about buying things from Craigslist. Later, after listening to Wade's fear of revealing himself to his lover, Vanessa Carlysle, Al encouraged the mercenary to reach out by stating that looks were only an aspect of love. After Vanessa was eventually kidnapped by Ajax, Wade, determined to rescue her, returned to Al's home and took all of the house's firearms, despite having to convince Al to hand over a pistol concealed in her sock. With that, the mercenary left the house after telling Al that there was "a stash of cocaine next to the cure for blindness".
After the death of Vanessa Carlysle, Deadpool broke into Blind Al's to retrieve some of the cocaine he had hidden there, which was next to the cure to blindness. Blind Al told him that she was sorry about Vanessa. After taking a massive hit, Deadpool headed off to make amends.
Later, after attempting to rescue Russell Collins from a prison convoy, Deadpool headed to Blind Al's to recover after being torn in two by Juggernaut as he needed to regrow the lower half of his body. While there, he was visited by Cable who proposed an alliance to stop Juggernaut.
Al is snarky, and tough, but has a good heart, for the most part. Though her and Wade trade insults, she does appear to genuinly care for him, acting as kind of a mother figure to him and offering advice. She appears to be a former cocaine addict and it is implied that she started doing it again after Wade left her some before leaving to kill Ajax.
- Cable - Ally and Former Enemy
- Deadpool - Friend and Ally
- Domino - Ally
- Dopinder - Ally
- Weasel - Ally
- In the comics, Blind Al is a Caucasian British woman. In the films, however, she is African-American.