- "I only have twelve bullets, so you’re going to have to share. Let’s count ‘em down."
The Highway Massacre is an event from 2010s of the revised timeline. Following a string of leads from various syndicates, Deadpool goes on a killing spree on a highway strip for his quest to confront Ajax.
After killing many of Francis's associates, Wade discovered his enemy's whereabouts and hitches a taxicab ride to the designated location the the location. While waiting in the cab, Wade sits bored in the backseat. He slides up front to chat with the cab, Dopinder. Deadpool asks Dopinder about a picture of a girl he has in his car, and Dopinder says she was his girlfriend until he lost her to his cousin. Deadpool realizes he forgot his bag of weapons and only has 12 rounds in his guns. Dopinder then takes Deadpool to the middle of a bridge, and Deadpool crisp high-fives the man for cab fare, due to the mercenary leaving his wallet at home, saying that it ruins the lining of his suit.
Deadpool waits on top of a bridge for his targets. He then spots a convoy of vans arriving, and, having found his target, jumps into one of the men before beating up of all the thugs in the van, causing an accident that kills other villains. Deadpool's main target is Ajax, the man that gave him his powers and also horribly disfigured him. The vans all come crashing to the end of the bridge, where one thug's head is slice off with a chain, and another one gets gorily splattered against a sign on the highway.
Having forgotten his ammo bag, and only having 12 bullets in his guns, Wade counts off how many rounds with each thug he kills, accidentally missing a few shots, but he manages to kill three men with one bullet. One last thug comes at Deadpool with two knives, but Deadpool quickly skewers him. Deadpool finds Ajax headed at him on a motorcycle and he throws his katana at the bike, causing Ajax to crash.
Following the ensuing chaos, Deadpool manages to impale Ajax with the other blade, but since Ajax has pain suppression, the blade doesn't kill him. Deadpool lifts up his mask for to show his scars so that Ajax can recognize him as Wade Wilson. Before Deadpool can do anything to Ajax, Colossus, having spotted Deadpool on the news, arrives with Negasonic Teenage Warhead and prevents Deadpool from proceeding.
Colossus is displeased with Deadpool causing so much mayhem and tries to get him to join the X-Men, to which Deadpool refuses. With his back turned, Ajax escapes. Enraged, Deadpool tries to hit Colossus, but he ends up breaking his hand. Deadpool then makes a few more futile attempts to injure Colossus, but to no avail, both of his hands and right foot are also broken. Colossus, having had enough of Deadpool's foolish and embarrassing attempts to injure him, sends Deadpool hurling into a car, then handcuffs the mercenary to his wrist, deciding to bring him to Professor X. Deadpool, with his limbs completely healed, chooses to cut his own cuffed hand off, and hop into a dump truck on the freeway below, leaving his hand to give Colossus the finger.
Deadpool rides the garbage truck back to his and Blind Al's place. After returning to the residence, Wade's hand starts to slowly grow back, gets convinced by Al into revealing himself to Vanessa.