- "Deadpool! That sounds like a fucking franchise!"
At some point, Weasel met and befriended Wade Wilson before putting him in a series of organized bar fights known as the "Deadpool". After Wade was diagnosed with cancer, Weasel comforted his friend by joking about his inevitable death. In desperation, Wade underwent an enhancement procedure, gaining a healing factor but getting disfigured in the process. Wade would then tell Weasel about his experience in the program and his desire to seek revenge against Ajax, who had been responsible for disfiguring him.
After getting an idea, Weasel convinced Wade into becoming a superhero known as Deadpool, the name inspired by the bar's matches. Later, Ajax and Angel Dust arrived at the bar in search of Wade Wilson, briefly threatening Weasel before discovering and targeting the mercenary's lover, Vanessa Carlysle. After learning of this, Wade took Weasel with him to find Vanessa, only for Ajax to promptly kidnap her. Determined to save his love, Wade went to Blind Al's house and armed himself for the impending confrontation, to which Weasel opted out of.
After the death of Vanessa Carlysle, Weasel tried to comfort Deadpool who had spent three days drinking at Sister Margaret's School for Wayward Children. Weasel also hired Dopinder to help in the bar, and ostensibly to train him as a contract killer although much of his duties involved cleaning.
Weasel helped Deadpool to assemble X-Force, holding auditions with him to screen potential team members. Cable later captured Weasel to find out about Deadpool's plan to rescue Russell Collins. Cable was prepared to torture Weasel, but Weasel just gave up the information since he did not want to get hurt.
- In the comics, Weasel often regards himself as Deadpool's best friend, although due to Deadpool's mental instability and erratic behavior, it leads to him abusing or mistreating Weasel.
- In the comics, Weasel is Deadpool's friend, sidekick, information broker, and arms dealer.